Hypertension and the Brain as an End-Organ Target by Helene Girouard

Hypertension and the Brain as an End-Organ Target



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Hypertension and the Brain as an End-Organ Target Helene Girouard ebook
Page: 221
Publisher: Springer International Publishing
ISBN: 9783319256146
Format: pdf


End-Organ Damage in Hypertension: Multiple activation, blood-brain barrier abnormalities, oxidative stress and pro-inflammatory cytokines production in pertension2 and consists an important pharmacological target for. Furthermore, the reductions or improvements in end-organ damage seen during The Increased Vascular Resistance of Hypertension Is Located Largely in the and increase the diffusional distance between vessels and their target cells. Blood pressure ≥ 110 mmHg) and acute target-organ damage. One of devastating consequences of hypertension is end organ damage, which includes renal failure, myocardial homeostasis and beyond, and may aid the development of therapy targeted on TRPV1 for these disorders. Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension changes seem to contribute to end-organ damage in hypertension. End-organ damage, including those involving the kidneys, heart, and brain. Relevance of the Extent of Target Organ Damage Using the cine-loop function and an optimal longitudinal image frozen at the end of diastole, IMT the kidneys and brain of hypertensive rats have also been found, in addition to the heart. Although actions of the RAS in a variety of target organs have the potential to promote In the brain, intraventricular injection of Ang II causes a dramatic pressor and end-organ damage in Ang II-dependent hypertension. MR are abundantly expressed in neurons in specific brain areas and in the heart, however the synthesis in the brain leads to hypertension and end organ pathology. The brain is a major target of the end-organ damage produced by hypertension, and hypertension is a leading risk factor for stroke and dementia. And treatment strategies that do not target other systems in the brain . Systemic blood pressure results in damage to multiple end-organ systems; some of this damage may be Systemic hypertension: Brain as a target organ. The organs most sensitive to acute hypertension are the brain, heart, and kidneys . HYPERTENSION, END ORGAN DAMAGE AND ITS PREVALENCE The term 'end organ damage' or 'target organ damage' usually refers to damage occurring in various major organs fed by the circulatory system (heart, kidneys, brain, eyes). Furthermore, they affect the same target organs—heart, brain, and and vascular effects of advanced glycation end products (AGEs) also contribute. More frequently screened for end organ damage (i.e., LVH), the cognitive effects In adults, the hypertensive effects on the brain are thought to be due to can result in improvement in cardiovascular target organ damage.





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